Coherence — Creating a $100B Industry at the Frontier of Neuroscience and Oncology
Over 25 years ago, a researcher stumbled on a fascinating discovery: when he cultured neurons in a dish with cancer cells, the cancer’s growth exploded. [1]
Bioelectronic communication governs everything from the thoughts in your head to the beat of your heart and yes, even how tumors grow, spread, and evade the immune system. The body is electric.
At Coherence, we believe the electrical language of the body is medicine’s next great unlock. We’ve quietly spent the last two years building the foundations of this new field. We’ve developed breakthrough neural interfaces to map the hidden electrical language of cancer. We’ve built advanced data pipelines and AI systems to decode them and track disease evolution in real time. And now, we’re introducing novel bioelectronic therapies to intervene directly, intelligently, and with unprecedented precision.
From aggressive brain cancers like glioblastoma, to treatment-resistant cancers like Triple Negative Breast Cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC)—we’re building a future where implantable technologies dramatically improve survival and quality of life.
Therapies that target a broad mechanism work for many cancers
While you’ll hear that we’re in the age of personalized ‘genetic’ medicine on repeat, therapies that target a single mutation in cancer tend to be less broadly applicable across cancers. This is why the most impactful cancer therapies—those that have done most to extend lifespan—have been those that work top-down. Surgery, chemotherapy, and radiotherapy are all cause-agnostic approaches. The last decade saw the emergence of a new class of top-down therapies, Immune Checkpoint Inhibitors (ICIs). And in this vein, Coherence is pioneering a futuristic new category: precision bioelectronic therapy delivered by neural interfaces.
Coherence is a new class of broadly applicable cancer therapies unlocked by neurotechnology.
As it stands today, cancer therapy has three pillars: drugs, radiotherapy, and surgery. We’re introducing a fourth: electricity, via bioelectronic therapy. Bioelectronic therapy offers huge potential across three modalities:
- Targeted electrotherapy: Direct electrotherapy on malignant cells
- Immunomodulation: Modulation of intrinsic immune forces using electrical stimulation
- Neuromodulation: Modulation of the supporting neural architecture that promotes disease
By directly modulating tumor tissue, disrupting neural support structures, and reprogramming the immune system, we’ve unlocked a new broadly applicable class of therapy for cancer.
Though we go beyond the other three pillars in a totally new way. Our bi-directional electrotherapy platform also records, generating real-time longitudinal data on the electrophysiology of cancer. No one has ever held a microscope to cancer 24/7 before.
Coherence brings a new approach to both cancer and neurotechnology:
Obsessively patient-driven. Science-led. Science-fiction-inspired.
Alongside our partners at Cambridge, Stanford, Monash, and the Royal Melbourne Hospital, we’ve built our first human-ready implantable devices and are preparing to enter the clinic in 2025.
We’re welcoming you to a new chapter in medicine—digitally controlled therapeutics that will reshape the future of cancer care and beyond. If the best-selling cancer immunotherapy, Keytruda, could sell $29.5 billion, Coherence will sell $100 billion.
This is the beginning of a new chapter in medicine—digitally controlled therapeutics that will reshape the future of healthcare. Beyond brain computer interfaces and towards disease-computer interfaces.
-- Ben Woodington, PhD - Co-founder & CEO Coherence.
The body runs on a bioelectronic
The body runs on a bioelectronic
Bioelectronic therapy at the cutting edge
Bioelectronic devices — tiny implants, smart wearables, and AI-powered neural systems — are a new interface between the human body and therapeutic technology.
The cutting edge of medicine is not only digital; it’s electric.
The body electric
Our bodies communicate both through chemicals like hormones and neurotransmitters and through electricity.
Tiny pulses of energy travel through nerves and tissues, orchestrating everything from your heartbeat to your thoughts. Neurons fire electrochemical impulses. The brain and nervous system function as complex, living circuits. Every sensation, movement, and emotion begins as an electrical signal.
This electrical activity forms the bioelectronic code — a language of patterns, frequencies, and pulses that governs how we function, feel, and heal.
Health and disease are not just chemical or genetic. They are also electrical.
When signals misfire or communication breaks down, illness can follow — from chronic pain and depression to autoimmune disorders, paralysis, and aggressive cancers like glioblastoma.
Cancer rewritten
Cancer isn’t just a genetic anomaly. It’s an active participant in the body’s electrical system.
Cancer monitors the body’s bioelectronic signals and responds with its own, hijacking the neural pathways used for healing and immune coordination to fuel its own growth.
At Coherence, we’re overwriting cancer’s bioelectronic signals.
The fourth pillar of cancer therapy
Cancer therapy has three pillars: drugs, radiotherapy, and surgery. We’re introducing a fourth pillar: electricity, via bioelectronic therapy. Bioelectronic therapy is divided into three primary modalities.
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A new era in disease management
Coherence products read the body’s electrical signals and deliver precise electrical modulation to areas affected by disease. This rebalances tissue function, relieves symptoms, supercharges immune response, and slows disease progression.
By bringing bioelectronic systems into stasis, we extend and improve quality of life.
Unlike chemotherapy or other systemic drugs, targeted bioelectronic therapy contends with disease at its source. Electrically modulating aberrant bioelectrical signals offers a precise approach to treating disease while substantially minimizing side effects compared to conventional cancer treatment.
Targeted bioelectronic therapy shows promise across many conditions:
- Restoring movement after paralysis through spinal or brain stimulation
- Reversing stroke damage by reactivating dormant neural pathways
- Treating depression or PTSD by rebalancing malfunctioning brain circuits
- Boosting immunity or suppressing cancer by modulating nerve-to-immune signals
The Coherence platform
Our approach is built on three interconnected pillars:
Neurotechnology
We design implantable electronics capable of sensing and stimulating with unmatched precision.
They’re small enough to fit on your fingertip, yet powerful enough to influence how the body behaves.
Neurobiology
We are mapping how cancer communicates with the nervous system and learning how to intervene.
In collaboration with partners at Cambridge, Monash, and Stanford, we’re pioneering the new field of electro-oncology.
AI & machine learning
Our closed-loop systems continuously learn from each patient.
We use advanced AI to decode high-resolution electrical signals and identify the unique fingerprint of each disease. These insights fuel personalized therapies that adapt in real time and provide clinicians with a new tool to understand and personalise treatment.
As we scale, we’re building the largest dataset of disease evolution and brain state in history, unlocking unprecedented insights into the brain and body.
Glioma management
SOMA-1 is our flagship device: a minimally invasive, MRI-safe brain–computer interface implanted during existing neurosurgery. SOMA-1 both monitors and treats brain disorders like gliomas in real time.
- Closed-loop stimulation reduces disease burden as it evolves.
- Continuous recording tracks tumor behavior without repeated scans.
- Adaptive AI personalizes therapy based on live data from the tumor environment.
SOMA-1 is therapy, diagnostics, and a living model — all in a device the size of a shirt button.
A patient-first paradigm
Gone are the days of burdensome treatments — no more head shaving, messy gel applications, bulky headgear that overheats, or cumbersome equipment.
With Coherence, patients can maintain their appearances and focus on enjoying life.
Patients are augmented by a holistic therapeutic system — a button-sized therapeutic implant; a modern, minimalist wearable that sits comfortably on top of the ear; and a user-friendly app.
This system greatly enhances quality of life — allowing patients to live easier, healthier, longer, and more joyful lives.
Bioelectronic cancer management
By decoding the body's electrical language, we’re unlocking a new way to understand and treat disease.
- Smarter: Personalized, real-time therapy for each patient.
- Faster: Deployable across conditions without years of redevelopment.
- Deeper: Reaching the core bioelectrical mechanisms of disease.
Coherence is laying the foundation of electro-oncology.
Welcome to a new paradigm in medicine.